{
 "query": "amlodipine / benazepril",
 "ingredient": "amlodipine / benazepril",
 "slug": "amlodipine-benazepril",
 "rxcui": "214223",
 "brands": [
  "Lotrel"
 ],
 "names": [
  "amlodipine / benazepril"
 ],
 "components": [
  {
   "ingredient": "amlodipine",
   "slug": "amlodipine",
   "grade": "A",
   "total": 90,
   "scores": {
    "safety": "A",
    "evidence": "C",
    "regulatory": "A",
    "conflict": "A",
    "options": "A"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "07/31/1992",
   "first_approval": "19920731"
  },
  {
   "ingredient": "benazepril",
   "slug": "benazepril",
   "grade": "C",
   "total": 73,
   "scores": {
    "safety": "C",
    "evidence": "F",
    "regulatory": "A",
    "conflict": "A",
    "options": "A"
   },
   "boxed": true,
   "controlled": false,
   "first_approval_fmt": "06/25/1991",
   "first_approval": "19910625"
  }
 ],
 "classes": [],
 "alternatives": [],
 "label": {},
 "faers": null,
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [],
 "recall_total": 0,
 "drugsfda": {
  "first_approval": "19910625",
  "first_approval_fmt": "",
  "anda": 12,
  "nda": 0,
  "rems": false,
  "labeling_recent": 0
 },
 "trials": null,
 "pubmed": null,
 "payments": {
  "year": "2024",
  "usd": 0.0,
  "records": 0,
  "by_name": [],
  "names_checked": [
   "amlodipine / benazepril",
   "Lotrel"
  ],
  "source": "bulk-index"
 },
 "partd": {
  "year": "2024",
  "claims": 1704619,
  "beneficiaries": 428095,
  "spend": 33242090.04,
  "by_brand": [
   {
    "brand": "Amlodipine Besylate-Benazepril",
    "claims": 1701710,
    "per_claim": 18.028569486,
    "is_generic": false
   },
   {
    "brand": "Lotrel",
    "claims": 2909,
    "per_claim": 880.95326916,
    "is_generic": false
   }
  ],
  "per_claim": 19.501184745682174
 },
 "mdl": [],
 "dsc": [],
 "settlements": [],
 "prescrire": null,
 "eml": null,
 "exposure": null,
 "scores": {
  "safety": {
   "score": 70,
   "letter": "C",
   "why": [
    "Graded by its riskiest ingredient, benazepril (70)",
    "Carries an FDA boxed warning, the strongest warning the FDA issues (-30)",
    "654 FDA reports naming it as the suspect drug per million Medicare fills, 0.2x the median drug on this site",
    "Death share in reports is near or below the FAERS average (0.9x)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 34,
   "letter": "F",
   "why": [
    "Graded by its riskiest ingredient, benazepril (34)",
    "117 randomized trials and 2 systematic reviews/meta-analyses indexed in PubMed",
    "No Cochrane review found (-5)",
    "Only 23% of completed registered trials posted results (-15)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 95,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, amlodipine (95)",
    "Recalls since 2016: 0 Class I, 0 Class II, 5 Class III across 40 generic makers (-1)",
    "2 label changes approved since 2021 (-4)"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 100,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, amlodipine (100)",
    "Pharma paid doctors $10,750 tied to this drug last year: negligible",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 100,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, amlodipine (100)",
    "Generic versions approved (40 applications)",
    "14 same-class alternatives exist"
   ],
   "weight": 0.1
  }
 },
 "total": 72,
 "grade": "C",
 "questions": [
  "This is a fixed combination of amlodipine and benazepril. Why both together, instead of only the one I need?",
  "The most-reported problems in FDA's adverse event data are fatigue, diarrhoea, nausea, dyspnoea. How would we recognize and handle those?",
  "Off-label use is among the most-reported items for this drug. Is my use on-label, and if not, what evidence supports it?",
  "Why this one over clevidipine, felodipine, isradipine? What would make you pick one of those instead?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)",
  "This drug carries a boxed warning. Which specific risk does it cover, and does it apply to me?",
  "The most-reported problems in FDA's adverse event data are fatigue, chronic kidney disease, diarrhoea. How would we recognize and handle those?",
  "Why this one over captopril, cilazapril, enalapril? What would make you pick one of those instead?"
 ]
}