{
 "query": "amylase / lipase / protease",
 "ingredient": "amylase / lipase / protease",
 "slug": "amylase-lipase-protease",
 "rxcui": "392491",
 "brands": [
  "Creon",
  "Pancreaze",
  "Pertzye",
  "Viokace",
  "Zenpep"
 ],
 "names": [
  "amylase / lipase / protease"
 ],
 "components": [
  {
   "ingredient": "amylase",
   "slug": "amylase",
   "grade": "B",
   "total": 84,
   "scores": {
    "safety": "A",
    "evidence": "D",
    "regulatory": "A",
    "conflict": "A",
    "options": "D"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "",
   "first_approval": ""
  },
  {
   "ingredient": "lipase",
   "slug": "lipase",
   "grade": "B",
   "total": 84,
   "scores": {
    "safety": "A",
    "evidence": "D",
    "regulatory": "A",
    "conflict": "A",
    "options": "F"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "",
   "first_approval": ""
  },
  {
   "ingredient": "protease",
   "slug": "protease",
   "grade": "B",
   "total": 85,
   "scores": {
    "safety": "A",
    "evidence": "C",
    "regulatory": "A",
    "conflict": "A",
    "options": "F"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "",
   "first_approval": ""
  }
 ],
 "classes": [],
 "alternatives": [],
 "label": {},
 "faers": null,
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [],
 "recall_total": 0,
 "drugsfda": {
  "first_approval": "",
  "first_approval_fmt": "",
  "anda": 0,
  "nda": 0,
  "rems": false,
  "labeling_recent": 0
 },
 "trials": null,
 "pubmed": null,
 "payments": {
  "year": "2024",
  "usd": 3974211.3699999996,
  "records": 79337,
  "by_name": [
   [
    "Creon",
    1997326.74
   ],
   [
    "Zenpep",
    1927517.65
   ],
   [
    "Pancreaze",
    40391.84
   ],
   [
    "Pertzye",
    8975.14
   ]
  ],
  "names_checked": [
   "amylase / lipase / protease",
   "Creon",
   "Zenpep",
   "Pancreaze",
   "Viokace",
   "Pertzye"
  ],
  "source": "bulk-index"
 },
 "partd": {
  "year": "2024",
  "claims": 1045960,
  "beneficiaries": 247072,
  "spend": 2112590035.83,
  "by_brand": [
   {
    "brand": "Creon",
    "claims": 775061,
    "per_claim": 1926.8768519,
    "is_generic": false
   },
   {
    "brand": "Zenpep",
    "claims": 259162,
    "per_claim": 2305.2623804,
    "is_generic": false
   },
   {
    "brand": "Pancreaze",
    "claims": 7942,
    "per_claim": 1565.4758197,
    "is_generic": false
   },
   {
    "brand": "Viokace",
    "claims": 2062,
    "per_claim": 1310.8927255,
    "is_generic": false
   },
   {
    "brand": "Pertzye",
    "claims": 1733,
    "per_claim": 3791.3775822,
    "is_generic": false
   }
  ],
  "per_claim": 2019.76178422693
 },
 "mdl": [],
 "dsc": [],
 "settlements": [],
 "prescrire": null,
 "eml": null,
 "exposure": null,
 "scores": {
  "safety": {
   "score": 92,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, protease (92)",
    "FDA issued 1 Drug Safety Communication(s) naming this drug since 2010, most recently 2012 (-8)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 50,
   "letter": "D",
   "why": [
    "Graded by its riskiest ingredient, amylase (50)",
    "115 randomized trials and 18 systematic reviews/meta-analyses indexed in PubMed",
    "2 independent Cochrane review(s) exist",
    "Only 9% of completed registered trials posted results (-15)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 100,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, amylase (100)",
    "No recalls on record since 2016"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 70,
   "letter": "C",
   "why": [
    "Graded by its riskiest ingredient, amylase (100)",
    "Pharma paid doctors $0 tied to this drug last year: negligible",
    "Not named in any pending federal MDL",
    "For the combination product itself:",
    "Pharma paid doctors $3,974,211 tied to this drug last year (-30)",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 40,
   "letter": "F",
   "why": [
    "Graded by its riskiest ingredient, lipase (40)",
    "No generic version approved: brand-only pricing (-30)",
    "No same-class alternatives found: little leverage to switch (-30)"
   ],
   "weight": 0.1
  }
 },
 "total": 74,
 "grade": "C",
 "questions": [
  "This is a fixed combination of amylase and lipase and protease. Why both together, instead of only the one I need?",
  "The most-reported problems in FDA's adverse event data are fatigue, nausea, decreased appetite, vomiting. How would we recognize and handle those?",
  "Why this one over lactase, pepsin a? What would make you pick one of those instead?",
  "There is no generic. Is there an older generic in the same class that works as well for my situation?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)",
  "The most-reported problems in FDA's adverse event data are diarrhoea, nausea, pyrexia, fatigue. How would we recognize and handle those?",
  "Off-label use is among the most-reported items for this drug. Is my use on-label, and if not, what evidence supports it?",
  "In 2012 the FDA issued a safety communication about this drug (Updated information on drug interactions between Victrelis (boceprevir) and certain boosted HIV protease inhib). Does that risk apply to me?",
  "The most-reported problems in FDA's adverse event data are asthenia, pyrexia, dizziness. How would we recognize and handle those?"
 ]
}