{
 "query": "aspirin",
 "ingredient": "aspirin",
 "slug": "aspirin",
 "rxcui": "1191",
 "brands": [
  "Aspi-Cor",
  "Bayer Aspirin",
  "Bufferin",
  "Durlaza",
  "Ecotrin",
  "Miniprin",
  "Norwich Aspirin",
  "St. Joseph Aspirin",
  "Vazalore"
 ],
 "names": [
  "aspirin"
 ],
 "classes": [
  {
   "id": "B01AC",
   "name": "Platelet aggregation inhibitors excl. heparin"
  },
  {
   "id": "N02BA",
   "name": "Salicylic acid and derivatives"
  }
 ],
 "alternatives": [
  "abciximab",
  "aloxiprin",
  "benorilate",
  "cangrelor",
  "choline salicylate",
  "cilostazol",
  "clopidogrel",
  "diflunisal",
  "dipyridamole",
  "epoprostenol",
  "eptifibatide",
  "ethenzamide",
  "iloprost",
  "imidazole-2-hydroxybenzoate",
  "indobufen",
  "morpholine salicylate",
  "potassium salicylate",
  "prasugrel",
  "salicylamide",
  "salsalate",
  "selexipag",
  "sodium salicylate",
  "ticagrelor",
  "ticlopidine",
  "tirofiban",
  "treprostinil",
  "triflusal",
  "vorapaxar"
 ],
 "label": {
  "route_mode": "ORAL",
  "route_counts": {
   "ORAL": 677,
   "RECTAL": 1
  },
  "boxed_warning": "",
  "indications_and_usage": "Uses Temporary relief of minor aches and pains due to: a cold headache backache muscular aches toothache minor pains from arthritis",
  "contraindications": "",
  "warnings_and_cautions": "",
  "warnings": "Warnings Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert: Aspirin may cause severe allergic reactions which may include: \u25a0 hives \u25a0 facial swelling \u25a0 shock \u25a0 asthma (wheezing) Stomach bleeding warning: This product contains an NSAID , which may cause severe stomach bleeding. The chance is higher if you: \u25a0 are age 60 or older \u25a0 have had stomach ulcers or bleeding problems \u25a0 take a blood thinning (anticoagulant) or steroid drug \u25a0 take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuproben, naproxen, or others) \u25a0 have 3 or more alcoholic drinks every day while using this product \u25a0 take more or for a longer time than directed Do not use \u25a0 if you have ever had an allergic reaction to any other pain reliever/fever reducer Ask a doctor before use if \u25a0 you have asthma \u25a0 stomach bleeding warning applies to you \u25a0 you have a history of stomach problems, such as heartburn \u25a0 you have...",
  "adverse_reactions": "",
  "drug_abuse_and_dependence": "",
  "controlled_substance": "",
  "recent_major_changes": "",
  "information_for_patients": "",
  "spl_medguide": "",
  "clinical_studies": "",
  "brand_name": "Rapidol Aspirin",
  "manufacturer": "Pharmadel LLC",
  "application_number": "M013",
  "pharm_class_epc": [
   "Nonsteroidal Anti-inflammatory Drug [EPC]",
   "Platelet Aggregation Inhibitor [EPC]"
  ],
  "route": [
   "ORAL"
  ],
  "effective_time": "20260706",
  "set_id": "00d9ab0d-ff25-784f-e063-6294a90a8497",
  "has_boxed_warning": false,
  "controlled": false,
  "mentions_rems": false
 },
 "faers": {
  "total": 547048,
  "serious": 404963,
  "death": 50904,
  "hospitalization": 221978,
  "primary_suspect": 545046,
  "top_reactions": [
   [
    "Fatigue",
    34798
   ],
   [
    "Diarrhoea",
    28715
   ],
   [
    "Dyspnoea",
    27891
   ],
   [
    "Nausea",
    26334
   ],
   [
    "Off Label Use",
    25531
   ],
   [
    "Drug Ineffective",
    24087
   ],
   [
    "Dizziness",
    21755
   ],
   [
    "Headache",
    20425
   ],
   [
    "Fall",
    19455
   ],
   [
    "Asthenia",
    19092
   ],
   [
    "Pain",
    18157
   ],
   [
    "Pneumonia",
    17113
   ],
   [
    "Death",
    16662
   ],
   [
    "Gastrointestinal Haemorrhage",
    16602
   ],
   [
    "Acute Kidney Injury",
    16463
   ]
  ],
  "by_year": {
   "2019": 55913,
   "2020": 49737,
   "2021": 42460,
   "2022": 35209,
   "2023": 30708,
   "2024": 30172,
   "2025": 31177,
   "2026": 14580
  },
  "by_year_primary": {
   "2019": 55860,
   "2020": 49684,
   "2021": 42292,
   "2022": 34761,
   "2023": 30279,
   "2024": 29900,
   "2025": 30824,
   "2026": 14415
  }
 },
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [
  {
   "class": "Class II",
   "date": "20220126",
   "reason": "CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.",
   "firm": "CARDINAL HEALTHCARE",
   "status": "Terminated"
  }
 ],
 "recall_total": 1,
 "drugsfda": {
  "applications": 4,
  "nda": 4,
  "anda": 0,
  "first_approval": "19650625",
  "rems": false,
  "rems_last": "",
  "labeling_supplements": 11,
  "labeling_recent": 1,
  "sponsors": [
   "BAYER",
   "HESP",
   "PLX PHARMA"
  ],
  "unapproved": false,
  "first_approval_fmt": "06/25/1965"
 },
 "trials": {
  "total": 2200,
  "completed": 1098,
  "terminated": 220,
  "with_results": 340,
  "industry": 550,
  "phase3": 431,
  "results_share": 0.30965391621129323,
  "terminated_share": 0.1
 },
 "pubmed": {
  "rct": 2377,
  "meta": 737,
  "recent_rct": 362,
  "cochrane": [
   {
    "pmid": "41919561",
    "title": "Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population",
    "year": "2026"
   },
   {
    "pmid": "41740630",
    "title": "Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population",
    "year": "2026"
   },
   {
    "pmid": "39775459",
    "title": "Oral and intranasal aspirin desensitisation for non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease",
    "year": "2025"
   },
   {
    "pmid": "32702783",
    "title": "Aspirin (single dose) for perineal pain in the early postpartum period",
    "year": "2020"
   },
   {
    "pmid": "32358837",
    "title": "Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss",
    "year": "2020"
   },
   {
    "pmid": "32352165",
    "title": "Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia",
    "year": "2020"
   },
   {
    "pmid": "31425623",
    "title": "Acetylsalicylic acid (aspirin) for schizophrenia",
    "year": "2019"
   },
   {
    "pmid": "29240976",
    "title": "Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events",
    "year": "2017"
   },
   {
    "pmid": "28181214",
    "title": "Aspirin (single dose) for perineal pain in the early postpartum period",
    "year": "2017"
   },
   {
    "pmid": "28084009",
    "title": "Aspirin for acute treatment of episodic tension-type headache in adults",
    "year": "2017"
   },
   {
    "pmid": "27807847",
    "title": "Aspirin for in vitro fertilisation",
    "year": "2016"
   },
   {
    "pmid": "26889740",
    "title": "Oral aspirin for treating venous leg ulcers",
    "year": "2016"
   }
  ]
 },
 "payments": {
  "year": "2024",
  "usd": 0.0,
  "records": 0,
  "by_name": [],
  "names_checked": [
   "aspirin",
   "Aspi-Cor",
   "Bayer Aspirin",
   "Bufferin",
   "Durlaza",
   "Ecotrin",
   "Miniprin",
   "Norwich Aspirin",
   "St. Joseph Aspirin",
   "Vazalore"
  ],
  "source": "bulk-index"
 },
 "partd": null,
 "mdl": [],
 "dsc": [
  {
   "date": "20160606",
   "title": "FDA warns about serious bleeding risk with over-the-counter antacid products containing aspirin",
   "url": "https://www.fda.gov/Drugs/DrugSafety/ucm504328.htm",
   "kind": "drug",
   "matched": "aspirin"
  },
  {
   "date": "20150709",
   "title": "FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes",
   "url": "https://www.fda.gov/Drugs/DrugSafety/ucm451800.htm",
   "kind": "drug",
   "matched": "aspirin"
  }
 ],
 "settlements": [],
 "prescrire": null,
 "eml": {
  "listed": false,
  "status": "",
  "name": "",
  "matched": null,
  "stewardship": []
 },
 "exposure": null,
 "scores": {
  "safety": {
   "score": 79,
   "letter": "B",
   "why": [
    "FDA issued 2 Drug Safety Communication(s) naming this drug since 2010, most recently 2016 (-16)",
    "Death share in reports is near or below the FAERS average (1.0x)",
    "Off-label use is among the five most-reported items: widely used beyond its approved evidence (-5)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 85,
   "letter": "B",
   "why": [
    "2377 randomized trials and 737 systematic reviews/meta-analyses indexed in PubMed",
    "12 independent Cochrane review(s) exist",
    "Only 31% of completed registered trials posted results (-15)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 97,
   "letter": "A",
   "why": [
    "Recalls since 2016: 0 Class I, 1 Class II, 0 Class III (-3)"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 100,
   "letter": "A",
   "why": [
    "Pharma paid doctors $0 tied to this drug last year: negligible",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 70,
   "letter": "C",
   "why": [
    "No generic version approved: brand-only pricing (-30)",
    "28 same-class alternatives exist"
   ],
   "weight": 0.1
  }
 },
 "total": 85,
 "grade": "B",
 "questions": [
  "In 2016 the FDA issued a safety communication about this drug (FDA warns about serious bleeding risk with over-the-counter antacid products containing aspirin). Does that risk apply to me?",
  "The most-reported problems in FDA's adverse event data are fatigue, diarrhoea, dyspnoea, nausea. How would we recognize and handle those?",
  "Off-label use is among the most-reported items for this drug. Is my use on-label, and if not, what evidence supports it?",
  "Why this one over abciximab, aloxiprin, benorilate? What would make you pick one of those instead?",
  "There is no generic. Is there an older generic in the same class that works as well for my situation?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)"
 ]
}