{
 "query": "bisoprolol / hydrochlorothiazide",
 "ingredient": "bisoprolol / hydrochlorothiazide",
 "slug": "bisoprolol-hydrochlorothiazide",
 "rxcui": "214317",
 "brands": [],
 "names": [
  "bisoprolol / hydrochlorothiazide"
 ],
 "components": [
  {
   "ingredient": "bisoprolol",
   "slug": "bisoprolol",
   "grade": "B",
   "total": 80,
   "scores": {
    "safety": "B",
    "evidence": "F",
    "regulatory": "A",
    "conflict": "A",
    "options": "A"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "07/31/1992",
   "first_approval": "19920731"
  },
  {
   "ingredient": "hydrochlorothiazide",
   "slug": "hydrochlorothiazide",
   "grade": "B",
   "total": 85,
   "scores": {
    "safety": "A",
    "evidence": "C",
    "regulatory": "B",
    "conflict": "A",
    "options": "A"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "02/24/1959",
   "first_approval": "19590224"
  }
 ],
 "classes": [],
 "alternatives": [],
 "label": {},
 "faers": null,
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [],
 "recall_total": 0,
 "drugsfda": {
  "first_approval": "19590224",
  "first_approval_fmt": "",
  "anda": 13,
  "nda": 0,
  "rems": false,
  "labeling_recent": 0
 },
 "trials": null,
 "pubmed": null,
 "payments": {
  "year": "2024",
  "usd": 0.0,
  "records": 0,
  "by_name": [],
  "names_checked": [
   "bisoprolol / hydrochlorothiazide"
  ],
  "source": "bulk-index"
 },
 "partd": {
  "year": "2024",
  "claims": 568303,
  "beneficiaries": 142073,
  "spend": 16561034.15,
  "by_brand": [
   {
    "brand": "Bisoprolol-Hydrochlorothiazide",
    "claims": 568266,
    "per_claim": 29.075973541,
    "is_generic": false
   },
   {
    "brand": "Ziac",
    "claims": 37,
    "per_claim": 1030.9991892,
    "is_generic": false
   }
  ],
  "per_claim": 29.141204867825792
 },
 "mdl": [],
 "dsc": [],
 "settlements": [],
 "prescrire": null,
 "eml": null,
 "exposure": null,
 "scores": {
  "safety": {
   "score": 83,
   "letter": "B",
   "why": [
    "Graded by its riskiest ingredient, bisoprolol (83)",
    "18,635 FDA reports naming it as the suspect drug per million Medicare fills, 6.7x the median drug on this site (-15)",
    "Death share in reports is near or below the FAERS average (1.2x)",
    "Serious outcomes are 1.7x the FAERS average share (-2)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 45,
   "letter": "F",
   "why": [
    "Graded by its riskiest ingredient, bisoprolol (45)",
    "214 randomized trials and 7 systematic reviews/meta-analyses indexed in PubMed",
    "On the WHO Model List of Essential Medicines (shown for context; no score effect)",
    "No Cochrane review found (-5)",
    "Only 31% of completed registered trials posted results (-15)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 85,
   "letter": "B",
   "why": [
    "Graded by its riskiest ingredient, hydrochlorothiazide (85)",
    "Recalls since 2016: 1 Class I, 0 Class II, 0 Class III across 36 generic makers (-15)"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 100,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, bisoprolol (100)",
    "Pharma paid doctors $0 tied to this drug last year: negligible",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 100,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, bisoprolol (100)",
    "Generic versions approved (13 applications)",
    "10 same-class alternatives exist"
   ],
   "weight": 0.1
  }
 },
 "total": 78,
 "grade": "B",
 "questions": [
  "This is a fixed combination of bisoprolol and hydrochlorothiazide. Why both together, instead of only the one I need?",
  "The most-reported problems in FDA's adverse event data are dyspnoea, acute kidney injury, fatigue, diarrhoea. How would we recognize and handle those?",
  "Why this one over acebutolol, atenolol, betaxolol? What would make you pick one of those instead?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)",
  "The most-reported problems in FDA's adverse event data are fatigue, nausea, diarrhoea. How would we recognize and handle those?",
  "Why this one over bendroflumethiazide, chlorothiazide, cyclopenthiazide? What would make you pick one of those instead?"
 ]
}