{
 "query": "calcium",
 "ingredient": "calcium",
 "slug": "calcium",
 "rxcui": "1895",
 "brands": [],
 "names": [
  "calcium"
 ],
 "classes": [],
 "alternatives": [],
 "label": {
  "route_mode": "ORAL",
  "route_counts": {
   "ORAL": 15
  },
  "boxed_warning": "",
  "indications_and_usage": "INDICATION & USAGE SECTION take two capsules once, two times a day",
  "contraindications": "",
  "warnings_and_cautions": "",
  "warnings": "WARNING Please check product ingredients if you have any allergies before taking. Please be careful during open the product package. Keep product out of direct sunlight, high temperature and humidity. Store in a cool dry place. Any items past the expiration date or damaged in transit can be exchanged where you originally purchased the item. consult your doctor if any abnormal symptoms occur",
  "adverse_reactions": "",
  "drug_abuse_and_dependence": "",
  "controlled_substance": "",
  "recent_major_changes": "",
  "information_for_patients": "",
  "spl_medguide": "",
  "clinical_studies": "",
  "brand_name": "GREAT CALCIUM",
  "manufacturer": "APEXEL CO., LTD.",
  "application_number": "",
  "pharm_class_epc": [
   "Calcium [EPC]"
  ],
  "route": [
   "ORAL"
  ],
  "effective_time": "20240123",
  "set_id": "11df7d66-7e85-d363-e063-6394a90ab59a",
  "has_boxed_warning": false,
  "controlled": false,
  "mentions_rems": false
 },
 "faers": {
  "total": 119387,
  "serious": 74261,
  "death": 8590,
  "hospitalization": 32402,
  "primary_suspect": 119270,
  "top_reactions": [
   [
    "Fatigue",
    12765
   ],
   [
    "Off Label Use",
    12254
   ],
   [
    "Drug Ineffective",
    9255
   ],
   [
    "Diarrhoea",
    8944
   ],
   [
    "Nausea",
    8931
   ],
   [
    "Pain",
    8657
   ],
   [
    "Arthralgia",
    8393
   ],
   [
    "Headache",
    7769
   ],
   [
    "Dyspnoea",
    6654
   ],
   [
    "Dizziness",
    6503
   ],
   [
    "Asthenia",
    5973
   ],
   [
    "Pain In Extremity",
    5719
   ],
   [
    "Vomiting",
    5572
   ],
   [
    "Malaise",
    5536
   ],
   [
    "Fall",
    5446
   ]
  ],
  "by_year": {
   "2019": 10567,
   "2020": 10609,
   "2021": 9883,
   "2022": 9101,
   "2023": 8421,
   "2024": 8191,
   "2025": 8005,
   "2026": 3843
  },
  "by_year_primary": {
   "2019": 10561,
   "2020": 10607,
   "2021": 9867,
   "2022": 9071,
   "2023": 8408,
   "2024": 8181,
   "2025": 7987,
   "2026": 3828
  }
 },
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [],
 "recall_total": 0,
 "drugsfda": {
  "applications": 0,
  "nda": 0,
  "anda": 0,
  "first_approval": "",
  "rems": false,
  "rems_last": "",
  "labeling_supplements": 0,
  "labeling_recent": 0,
  "sponsors": [],
  "unapproved": false,
  "first_approval_fmt": ""
 },
 "trials": {
  "total": 5778,
  "completed": 3266,
  "terminated": 587,
  "with_results": 1082,
  "industry": 1734,
  "phase3": 870,
  "results_share": 0.3312921004286589,
  "terminated_share": 0.10159224645205954
 },
 "pubmed": {
  "rct": 3371,
  "meta": 711,
  "recent_rct": 344,
  "cochrane": [
   {
    "pmid": "41330480",
    "title": "Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems",
    "year": "2025"
   },
   {
    "pmid": "40965861",
    "title": "Calcium supplementation commenced before pregnancy for preventing hypertensive disorders and related problems",
    "year": "2025"
   },
   {
    "pmid": "39560075",
    "title": "Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes",
    "year": "2024"
   },
   {
    "pmid": "38721870",
    "title": "Calcium supplementation for people with overweight or obesity",
    "year": "2024"
   },
   {
    "pmid": "37975597",
    "title": "Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion-dependent beta thalassaemia",
    "year": "2023"
   },
   {
    "pmid": "36705288",
    "title": "Calcium and vitamin D for increasing bone mineral density in premenopausal women",
    "year": "2023"
   },
   {
    "pmid": "35014026",
    "title": "Calcium supplementation for prevention of primary hypertension",
    "year": "2022"
   },
   {
    "pmid": "35000192",
    "title": "Calcium channel blockers versus other classes of drugs for hypertension",
    "year": "2022"
   },
   {
    "pmid": "34657281",
    "title": "Calcium channel blockers versus other classes of drugs for hypertension",
    "year": "2021"
   },
   {
    "pmid": "34693985",
    "title": "Calcium supplementation for prevention of primary hypertension",
    "year": "2021"
   },
   {
    "pmid": "33000470",
    "title": "Calcium channel blockers for people with chronic kidney disease requiring dialysis",
    "year": "2020"
   },
   {
    "pmid": "32303107",
    "title": "Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children",
    "year": "2020"
   }
  ]
 },
 "payments": {
  "year": "2024",
  "usd": 0.0,
  "records": 0,
  "by_name": [],
  "names_checked": [
   "calcium"
  ],
  "source": "bulk-index"
 },
 "partd": {
  "year": "2024",
  "claims": 384757,
  "beneficiaries": 107105,
  "spend": 27572954.47,
  "by_brand": [
   {
    "brand": "Calcium Acetate",
    "claims": 384757,
    "per_claim": 71.663295197,
    "is_generic": true
   }
  ],
  "per_claim": 71.66329519670857
 },
 "mdl": [],
 "dsc": [],
 "settlements": [],
 "prescrire": null,
 "eml": {
  "listed": true,
  "status": "AddedToEml",
  "name": "calcium",
  "matched": "calcium",
  "stewardship": []
 },
 "exposure": {
  "years": [
   "2024",
   "2025",
   "2026"
  ],
  "reports_recent": 19996,
  "fills": 384757,
  "per_million": 51970.46447498031,
  "ratio": 18.769016810015227,
  "median": 2768.949753790441
 },
 "scores": {
  "safety": {
   "score": 80,
   "letter": "B",
   "why": [
    "51,970 FDA reports naming it as the suspect drug per million Medicare fills, 18.8x the median drug on this site (-15)",
    "Death share in reports is near or below the FAERS average (0.8x)",
    "Off-label use is among the five most-reported items: widely used beyond its approved evidence (-5)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 85,
   "letter": "B",
   "why": [
    "3371 randomized trials and 711 systematic reviews/meta-analyses indexed in PubMed",
    "On the WHO Model List of Essential Medicines (shown for context; no score effect)",
    "12 independent Cochrane review(s) exist",
    "Only 33% of completed registered trials posted results (-15)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 100,
   "letter": "A",
   "why": [
    "No recalls on record since 2016"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 100,
   "letter": "A",
   "why": [
    "Pharma paid doctors $0 tied to this drug last year: negligible",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 40,
   "letter": "F",
   "why": [
    "No generic version approved: brand-only pricing (-30)",
    "No same-class alternatives found: little leverage to switch (-30)"
   ],
   "weight": 0.1
  }
 },
 "total": 83,
 "grade": "B",
 "questions": [
  "The most-reported problems in FDA's adverse event data are fatigue, diarrhoea. How would we recognize and handle those?",
  "Off-label use is among the most-reported items for this drug. Is my use on-label, and if not, what evidence supports it?",
  "There is no generic. Is there an older generic in the same class that works as well for my situation?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)"
 ]
}