{
 "query": "formoterol / mometasone",
 "ingredient": "formoterol / mometasone",
 "slug": "formoterol-mometasone",
 "rxcui": "1002293",
 "brands": [
  "Dulera"
 ],
 "names": [
  "formoterol / mometasone"
 ],
 "components": [
  {
   "ingredient": "formoterol",
   "slug": "formoterol",
   "grade": "A",
   "total": 94,
   "scores": {
    "safety": "A",
    "evidence": "B",
    "regulatory": "A",
    "conflict": "A",
    "options": "A"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "02/16/2001",
   "first_approval": "20010216"
  },
  {
   "ingredient": "mometasone",
   "slug": "mometasone",
   "grade": "B",
   "total": 84,
   "scores": {
    "safety": "A",
    "evidence": "C",
    "regulatory": "A",
    "conflict": "B",
    "options": "A"
   },
   "boxed": false,
   "controlled": false,
   "first_approval_fmt": "04/30/1987",
   "first_approval": "19870430"
  }
 ],
 "classes": [],
 "alternatives": [],
 "label": {},
 "faers": null,
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [],
 "recall_total": 0,
 "drugsfda": {
  "first_approval": "19870430",
  "first_approval_fmt": "",
  "anda": 10,
  "nda": 0,
  "rems": false,
  "labeling_recent": 0
 },
 "trials": null,
 "pubmed": null,
 "payments": {
  "year": "2024",
  "usd": 0.0,
  "records": 0,
  "by_name": [],
  "names_checked": [
   "formoterol / mometasone",
   "Dulera"
  ],
  "source": "bulk-index"
 },
 "partd": {
  "year": "2024",
  "claims": 369910,
  "beneficiaries": 105783,
  "spend": 162082132.71,
  "by_brand": [
   {
    "brand": "Dulera",
    "claims": 369910,
    "per_claim": 438.16639915,
    "is_generic": false
   }
  ],
  "per_claim": 438.1663991511449
 },
 "mdl": [],
 "dsc": [],
 "settlements": [],
 "prescrire": null,
 "eml": null,
 "exposure": null,
 "scores": {
  "safety": {
   "score": 93,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, mometasone (93)",
    "6,044 FDA reports naming it as the suspect drug per million Medicare fills, 2.2x the median drug on this site (-7)",
    "Death share in reports is near or below the FAERS average (0.4x)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 63,
   "letter": "C",
   "why": [
    "Graded by its riskiest ingredient, mometasone (63)",
    "221 randomized trials and 12 systematic reviews/meta-analyses indexed in PubMed",
    "On the WHO Model List of Essential Medicines (shown for context; no score effect)",
    "No Cochrane review found (-5)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 88,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, mometasone (88)",
    "Recalls since 2016: 0 Class I, 2 Class II, 4 Class III across 25 generic makers (-4)",
    "10 label changes approved since 2021: the safety story is still moving (-8)"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 85,
   "letter": "B",
   "why": [
    "Graded by its riskiest ingredient, mometasone (85)",
    "Pharma paid doctors $337,030 tied to this drug last year (-15)",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 100,
   "letter": "A",
   "why": [
    "Graded by its riskiest ingredient, formoterol (100)",
    "Generic versions approved (10 applications)",
    "16 same-class alternatives exist"
   ],
   "weight": 0.1
  }
 },
 "total": 84,
 "grade": "B",
 "questions": [
  "This is a fixed combination of formoterol and mometasone. Why both together, instead of only the one I need?",
  "The most-reported problems in FDA's adverse event data are dyspnoea, asthma, cough, wheezing. How would we recognize and handle those?",
  "Why this one over albuterol, bambuterol, bitolterol? What would make you pick one of those instead?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)",
  "The most-reported problems in FDA's adverse event data are dyspnoea, no adverse event, product quality issue. How would we recognize and handle those?",
  "Why this one over amcinonide, beclomethasone, betamethasone? What would make you pick one of those instead?"
 ]
}