{
 "query": "lithium",
 "ingredient": "lithium",
 "slug": "lithium",
 "rxcui": "6448",
 "brands": [],
 "names": [
  "lithium",
  "lithium orotate",
  "lithium silicate"
 ],
 "classes": [
  {
   "id": "N05AN",
   "name": "Lithium"
  }
 ],
 "alternatives": [],
 "label": {
  "route_mode": "ORAL",
  "route_counts": {
   "ORAL": 6
  },
  "boxed_warning": "",
  "indications_and_usage": "",
  "contraindications": "",
  "warnings_and_cautions": "",
  "warnings": "",
  "adverse_reactions": "",
  "drug_abuse_and_dependence": "",
  "controlled_substance": "",
  "recent_major_changes": "",
  "information_for_patients": "",
  "spl_medguide": "",
  "clinical_studies": "",
  "brand_name": "Lithium Metallicum",
  "manufacturer": "Hahnemann Laboratories, INC.",
  "application_number": "",
  "pharm_class_epc": [],
  "route": [
   "ORAL"
  ],
  "effective_time": "20230516",
  "set_id": "fbdc435e-2ad0-8663-e053-6294a90a4c18",
  "has_boxed_warning": false,
  "controlled": false,
  "mentions_rems": false
 },
 "faers": {
  "total": 19011,
  "serious": 15178,
  "death": 1530,
  "hospitalization": 8005,
  "primary_suspect": 18752,
  "top_reactions": [
   [
    "Toxicity To Various Agents",
    2045
   ],
   [
    "Drug Ineffective",
    1952
   ],
   [
    "Off Label Use",
    1485
   ],
   [
    "Drug Interaction",
    1298
   ],
   [
    "Tremor",
    1158
   ],
   [
    "Nausea",
    1086
   ],
   [
    "Weight Increased",
    857
   ],
   [
    "Fatigue",
    845
   ],
   [
    "Vomiting",
    799
   ],
   [
    "Anxiety",
    767
   ],
   [
    "Condition Aggravated",
    725
   ],
   [
    "Depression",
    718
   ],
   [
    "Somnolence",
    712
   ],
   [
    "Suicidal Ideation",
    700
   ],
   [
    "Insomnia",
    653
   ]
  ],
  "by_year": {
   "2019": 1829,
   "2020": 1808,
   "2021": 1574,
   "2022": 1715,
   "2023": 1735,
   "2024": 1563,
   "2025": 1415,
   "2026": 678
  },
  "by_year_primary": {
   "2019": 1827,
   "2020": 1798,
   "2021": 1551,
   "2022": 1677,
   "2023": 1687,
   "2024": 1507,
   "2025": 1359,
   "2026": 654
  }
 },
 "faers_base": {
  "total": 20692304,
  "serious_share": 0.5742697381596559,
  "death_share": 0.09102355155810585
 },
 "recalls": [],
 "recall_total": 0,
 "drugsfda": {
  "applications": 0,
  "nda": 0,
  "anda": 0,
  "first_approval": "",
  "rems": false,
  "rems_last": "",
  "labeling_supplements": 0,
  "labeling_recent": 0,
  "sponsors": [],
  "unapproved": false,
  "first_approval_fmt": ""
 },
 "trials": {
  "total": 462,
  "completed": 250,
  "terminated": 50,
  "with_results": 83,
  "industry": 93,
  "phase3": 61,
  "results_share": 0.332,
  "terminated_share": 0.10822510822510822
 },
 "pubmed": {
  "rct": 539,
  "meta": 183,
  "recent_rct": 63,
  "cochrane": [
   {
    "pmid": "31152444",
    "title": "Lithium for acute mania",
    "year": "2019"
   },
   {
    "pmid": "26509923",
    "title": "Lithium for schizophrenia",
    "year": "2015"
   },
   {
    "pmid": "26374731",
    "title": "Hemodialysis for lithium poisoning",
    "year": "2015"
   },
   {
    "pmid": "17636738",
    "title": "Lithium for schizophrenia",
    "year": "2007"
   },
   {
    "pmid": "17054174",
    "title": "Lithium versus antidepressants in the long-term treatment of unipolar affective disorder",
    "year": "2006"
   },
   {
    "pmid": "12917990",
    "title": "Lithium for schizophrenia",
    "year": "2003"
   },
   {
    "pmid": "11687035",
    "title": "Lithium for maintenance treatment of mood disorders",
    "year": "2001"
   },
   {
    "pmid": "11406061",
    "title": "Lithium for maintenance treatment of mood disorders",
    "year": "2001"
   }
  ]
 },
 "payments": {
  "year": "2024",
  "usd": 0.0,
  "records": 0,
  "by_name": [],
  "names_checked": [
   "lithium"
  ],
  "source": "bulk-index"
 },
 "partd": {
  "year": "2024",
  "claims": 1009,
  "beneficiaries": 327,
  "spend": 138520.89,
  "by_brand": [
   {
    "brand": "Lithium Citrate",
    "claims": 1009,
    "per_claim": 137.2853221,
    "is_generic": true
   }
  ],
  "per_claim": 137.2853221010902
 },
 "mdl": [],
 "dsc": [],
 "settlements": [],
 "prescrire": null,
 "eml": {
  "listed": false,
  "status": "",
  "name": "",
  "matched": null,
  "stewardship": []
 },
 "exposure": null,
 "scores": {
  "safety": {
   "score": 95,
   "letter": "A",
   "why": [
    "Death share in reports is near or below the FAERS average (0.9x)",
    "Off-label use is among the five most-reported items: widely used beyond its approved evidence (-5)"
   ],
   "weight": 0.35
  },
  "evidence": {
   "score": 76,
   "letter": "B",
   "why": [
    "539 randomized trials and 183 systematic reviews/meta-analyses indexed in PubMed",
    "8 independent Cochrane review(s) exist",
    "Only 33% of completed registered trials posted results (-15)"
   ],
   "weight": 0.25
  },
  "regulatory": {
   "score": 100,
   "letter": "A",
   "why": [
    "No recalls on record since 2016"
   ],
   "weight": 0.15
  },
  "conflict": {
   "score": 100,
   "letter": "A",
   "why": [
    "Pharma paid doctors $0 tied to this drug last year: negligible",
    "Not named in any pending federal MDL"
   ],
   "weight": 0.15
  },
  "options": {
   "score": 40,
   "letter": "F",
   "why": [
    "No generic version approved: brand-only pricing (-30)",
    "No same-class alternatives found: little leverage to switch (-30)"
   ],
   "weight": 0.1
  }
 },
 "total": 86,
 "grade": "B",
 "questions": [
  "The most-reported problems in FDA's adverse event data are toxicity to various agents, drug interaction. How would we recognize and handle those?",
  "Off-label use is among the most-reported items for this drug. Is my use on-label, and if not, what evidence supports it?",
  "There is no generic. Is there an older generic in the same class that works as well for my situation?",
  "What result are we expecting, by when, and what is the plan if it does not happen?",
  "If 100 people like me took this drug, how many would actually get better because of it, and how many would be harmed by it? (Doctors call these the number needed to treat and the number needed to harm.)"
 ]
}